major depressive disorders (MDD) witnessed today in mental health clinics across the world.
The position and perspective of this author is that the chief cause of MDD seen in clinical practice today is cognitive-behavioral.
Childhood trauma, chronic stress, and anxiety all alter chemical pathways in the human brain which leads to a decrease in key neurotransmitter levels. This in turn correlates to a major depressive episode in later life. These facts are irrefutable and independent of any hypothesized “genetic” predisposition or hereditary component.
Supporting Argument 1:
In the research performed by Murrough, et al, and published in the 2011 September issue of the Journal of American Medical Association, (JAMA Psychiatry), there is empirical evidence to support the idea that an incidence of trauma at an early age produces neurobiological and behavioral alterations in the human body suggesting a developmental component in the cause of Post-Traumatic Stress Disorder (PTSD) with a high comorbity with MDD (Murrough, et al, 2011).
Supporting Argument 2:
In another study by Dr. J. Hovens in 2012 and published in the Acta Psychiatrica Scandinavica, a longitudinal study of childhood trauma victims over a two year period resulted in high incidences of MDD with individuals who experienced “emotional neglect” and “psychological abuse” (Hovens, et al., 2012).
Supporting Argument 3:
In a study by C. Cutrona in 2006, the effects of a contextual involvement for depression becomes clear. Within her research, Cutrona takes into account that a prolonged exposure to stress and anxiety within this context can also produce an “environment” (such as a neighborhood and threats of victimization) that leads to depression (Cutrona, 2006).
Supporting argument 4:
In his article for the Psychological Bulletin in 2008, Edward Watkins gives the psychological community a link between the outcomes on depression and repetitive thought, or RT. This has to deal with self-esteem and whether or not our repetitive thoughts are “constructive” or “destructive” (Watkins, 2008). Destructive RT can have negative consequences and prolonged exposure can lead to MDD if not held in check.
John
References:
Cutrona, C. E., Wallace, G., & Wesner, K. A. (2006). Neighborhood characteristics
and depression: An examination of stress processes. Current Directions in Psychological Science, 15(4), 188–192.
Hovens, J., Giltay, E., Wiersma, J., Spinhoven, P., Penninx, J., & Zitman, F. (2012).
Impact of childhood life events and trauma on the course of depressive and anxiety disorders. Acta Psychiatrica Scandinavica. 126, 198-207
Murrough, J. Czermak, C., Henry, S., Nabulsi, N., Gallezot, J., et al. (2011) The
Effect of Early Trauma Exposure on Serotonin Type 1B Receptor Expression Revealed by Reduced Selective Radioligand Binding. JAMA Psychiatry, 68, (9), 892-900. Retrieved from Capella University Library, EBSCOhost http://web.b.ebscohost.com.library.capella.edu/ehost/command/detail?sid=9fc5a9ad-f6f5-48d1-8f8e-0a82655e27bd%40sessionmgr113&vid=23&hid=119
Watkins, E., (2008), Constructive and Unconstructive Repetitive Thought,
Psychological Bulletin, (134), (2), 163–206. Retrieved from Capella Library, EBSCOhost, http://web.a.ebscohost.com.library.capella.edu/ehost/pdfviewer/pdfviewer?sid=a0a19980-b2af-48d8-b2ca-d48eab7dfa2c%40sessionmgr4001&vid=7&hid=4201
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